mtr - perhaps you haven't tried Killer Sudokus before?
Starting tips - you can enter candidates in the 2-cell cages that have only one pair as an option. Thus: Row 1, cage of 3 must have 1 and 2 as candidates, likewise row 7, cage of 16 = 7+9, row 9 cage of 4 = 1+3 though you don't know which way round they go at this stage.
After that, look at Box (nonet) 1. 13+9+9=31. Thus the remaining 3 cells must add to 14. Thus in box 2, the balance of the 8-cell 44 cage must add to 30. 30+3+13 = 46, therefore r4c6 = 1.
You can do the same for box 3 and 6 to calculate r6c6; box 9 and 8 to calculate r6c4; and box 7 and 4 to calculate r4c4. These 4 digits in the corners of box 5 should add up to 14!
Hope that helps.