Well I created the beast! (On MX Linux with Python script) The database is ~506 GiB and a query takes about 28 minutes. It seems to work.
I have other ideas about dynamically creating a database of just the sudz file you need and not 'persisting' any large database. Concept is very doable.
I am just trying to find the motivation to do so. Kinda like the ole Chicago 1 song. Does anyone know what time it is? Does anybody really care?
Maybe, I will do it, just to prove I can, but right now I DON"T REALLY CARE!