This one's tough, eek!! What I have so far...:
6*2 *** 9**
*** 2** *** (first 3 grids, left to right) * = blank
**9 3** *42
*** 7** 61*
576 418 239 (middle 3 grids)
*91 **3 ***
*1* **7 5**
*** 1*4 *** (bottom 3 grids)
**3 *** 1*7
Any assistance would be welcome, though I hope for just a hint -- one to two numbers and how they were proved, as I think when I get a few more I can get the whole puzzle. Thanks in advance! =p.